Zhang Zhiqiang

Lecturer

ADDRESS：No.166, Kexue Road, Zhengzhou, Henan province, China.

PHONE：+86-371-86609676

FAX：+86-371-86609676

E-mail：zhangzq@zzuli.edu.cn

Websites：

Research interests：

Development of quantum chemical methods, theoretical research on catalytic mechanism.

Education:

1997/9 - 2001/6，Department of Chemistry, Zhengzhou University, Bachelor of Science.

2001/9 - 2004/6，Department of Chemical Physics, University of Science and Technology of China, Master of Science.

2004/9 - 2007/11，Department of Biology and Chemistry, City University of Hongkong, Doctor of Philosophy.

Course taught:

Structural Chemistry, Specialty English, Medicinal Chemistry

Research achievements（textbook, paper, patent, etc.）：

Paper:

[1] *Zhang Z. Q., Xu L. C., Wang G. Q., Shao C. and Jiang L., The development and validation of a pseudoatoms approach for combined quantum mechanics and molecular mechanics calculations of polypeptide, Comput. Theor. Chem., 2014, 1043:38-46.

[2] *Zhang Z. Q., Xu L. C. and Cheung H. Y., The inhibitory effect of helenalin on telomerase activity is attributed to the alkylation of the CYS445 residue: Evidence from QM/MM simulations, J. Mol. Graph. Model., 2014, 51:97-103.

[3]Zhang Z. Q., *Xu L. C. and Feng W. K., Intermolecular proton transfer in cyclic carbonate synthesis from epoxide and carbon dioxide catalyzed by azaphosphatranes: a DFT mechanistic study, Rsc. Adv., 2015, 5(16): 12382-12386.

[4] Zhang Y. X., *Qu X., Yu J. P., Xu L. C.,Zhang Z. Q., Hong H. and Liu C. S., C-13 NMR aided design of molecularly imprinted adsorbents for selectively preparative separation of erythromycin, J. Mater. Chem. B, 2014, 2(10): 1390-1399.

[5] Xu L. C.,* Li Q. S.,Zhang Z. Q., Miao T. F., Zheng K. C. and Ji L. N., A theoretical study on the substituent effect of DNA-photocleavage by [Ru(phen)(2)(6-R-dppz)](2+) (R = H, OH, and NO2), J. Mol. Struc-Theochem, 2010, 961(1-3): 35-41.

[6] Zhou H. W., Lai W. P.,Zhang Z. Q., Li W. K. and *Cheung H. Y., Computational study on the molecular inclusion of andrographolide by cyclodextrin, J. Comput. Aided Mol. Des., 2009, 23(3): 153-162.

[7] Zhou H. W.,Zhang Z. Q.and *Cheung H. Y., Theoretical Study on the Reactive Sites and Intramolecular Interactions in Taxol and Its Four Analogues, Int. J. Quantum Chem, 2009, 109(2): 362-372.

[8]Zhang Z. Q., Chow R. K. K., Zhou H. W., Li J. L. and *Cheung H. Y., An ab initio study on the structure-cytotoxicity relationship of terpenoid lactones based on the Michael reaction between their pharmacophores and L-cysteine-methylester(-1), J. Theor. Comput. Chem., 2008, 7(3): 347-356.

[9]Zhang Z. Q., Chan G. K. L., Li J. L., Fong W. F. and *Cheung H. Y., Molecular interaction between andrographolide and glutathione follows second order kinetics, Chem. Pharm. Bull., 2008, 56(9): 1229-1233.

[10] Li J. L., *Cheung H. Y.,Zhang Z. Q., Chan G. K. L. and Fong W. F., Andrographolide induces cell cycle arrest at G2/M phase and cell death in HepG2 cells via alteration of reactive oxygen species, Eur. J. Pharmacol., 2007, 568(1-3): 31-44.

[11]Zhang Z. Q., Hu C. J., Pei L. S., Chen C. X. and *Chen Y., The rate constants of the reactions of NCO with SO2 or CS2, Acta Phys-Chim. Sin., 2004, 20(5): 535-539.

Ongoing projects:

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