基于DNA链置换反应的圆环形逻辑门设计

郑州轻工业学院电气信息工程学院, 河南郑州 450002
基金项目:河南省基础与前沿技术研究计划项目(142300413214)
河南省高校科技创新人才支持计划资助项目(15HASTIT019)
河南省高等学校青年骨干教师资助计划项目(2013GGJS—106)
国家自然科学基金项目(61472371,61472372,61572446)
中图分类号:TP331;Q811.4

Design of circular logic gate based on DNA strand displacement reaction

College of Electric Information Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China
Received Date:2015-11-19
Available Online:2016-01-15
CLC number:TP331;Q811.4

摘要:利用DNA链置换技术反应进程的可编程性和DNA链动力学特征的可预测性,基于DNA链置换反应,以圆环形DNA为基本单元,构造出与非门和或非门逻辑计算模型.该模型以单链DNA分子为输入信号,利用圆环形DNA分子包含的多个DNA识别区域和小支点区域,通过探测荧光信号精确识别其输出信号,来确保DNA分子逻辑门输出结果的正确性与广泛适用性.
- DNA链置换反应/
- 圆环形DNA/
- 逻辑门
Abstract:Using the DNA strand displacement technology that the reaction progress was programmable and the DNA strand dynamics was predictable, two logic computational models (logic NAND gate and NOR gate) with circular DNA as a basic work unit were designed based on DNA strand displacement reaction. In these models, single-stranded DNA was regarded as the system input. Using many DNA recognition domains and toehold domains which were contained in circular DNA molecule,the output signal was accurately identified by detecting specific fluorescent signal to ensure the correctness and extensive applicability of these DNA logic gate models.
- DNA strand displacement reaction/
- circular DNA/
- logic gate
1. [1]
  MAO C,LABEAN T H,REIF J H,et al.Logical computation using algorithmic self-assembly of DNA triple-crossover molecules[J].Nature,2000,407(6803):493.
2. [2]
  WANG Y F,SUN J W,CUI G Z,et al.Basic logical operations using algorithmic self-assembly of DNA molecules[J].Journal of nanoelectronics and optoelectronics,2010,5(1):30.
3. [3]
  WANG Y F,SUN J W,ZHANG X C,et al.Half adder and half subtractor operations by DNA self-assembly[J].Journal of computational and theoretical nanoscience,2011,8(7):1288.
4. [4]
  WANG Y F,SUN J W,ZHANG X C,et al.Full adder and full subtractor operations by DNA self-assembly[J].Advanced science letters,2011,4(2):383.
5. [5]
  WANG Y F,SUN J W,CUI G Z,et al.Logical NAND and NOR operations using algorithmic self-assembly of DNA molecules[J].Physics procedia,2012,33:954.
6. [6]
  FREZZA B M,COCKROFT S L,GHADIRI M R.Modular multi-level circuits from immobilized DNA-based logic gates[J].Journal of the american chemical society,2007,129(48):14875.
7. [7]
  ZHANG D Y,SEELIG G.Dynamic DNA nanotechnology using strand-displacement reactions[J].Nature chemistry,2011,3(2):103.
8. [8]
  MITEHDL J C,YURKE B. DNA Scissors[C]//DNA Computing:7th International Workshop on DNA-Based Computers,Heidelberg:Springer,2002: 258-268.
9. [9]
  SHIN J S,PIERCE N A.A synthetic DNA walker for molecular transport[J].Journal of the american chemical society,2004,126(35):10834.
10. [10]
  LUND K,MANZO A J,DABBY N,et al.Molecular robots guided by prescriptive landscapes[J]. Nature,2010,465(7295):206.
11. [11]
  LI W,YANG Y,YAN H,et al.Three-input majority logic gate and multiple input logic circuit based on DNA strand displacement[J].Nano letters,2013,13(6):2980.
12. [12]
  周康, 王延峰, 刘文斌, 等. 基于闭环DNA的边着色问题DNA算法[J]. 华中科技大学学报(自然科学版), 2006, 34(9): 25.
13. [13]
  ZHANG C, YANG J, XU J. Circular DNA logic gates with strand displacement[J].Langmuir,2010,26(3):1416.
14. [14]
  WANG Z G,WILNER O I,ITAMAR W. Self-assembly of aptamer-circular DNA nanostructures for controlled biocatalysis[J].Nano letters,2009,9(12):4098.
15. [15]
  WEIZMANN Y,BRAUNSCHWEIG A B,WILNER O I,et al.A polycatenated DNA scaffold for the one-step assembly of hierarchical nanostructures[J].Proceedings of the national academy of sciences,2008,105(14):5289.
1. [1]
  孙军伟,李幸,黄春. 基于DNA链置换的多位全减器逻辑运算. 轻工学报, 2016, 31(6): 54-61.doi: 10.3969/j.issn.2096-1553.2016.6.008
2. [2]
  姚莉娜,田桂花,叶盟盟,赵涛涛,崔光照,王延峰. DNA链置换技术的研究现状与展望. 轻工学报, 2014, 29(1): 15-21.doi: 10.3969/j.issn.2095-476X.2014.01.003
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4. [4]
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9. [9]
  黄春,侯贺伟,叶盟盟,李萌萌,崔光照,王延峰. 结构DNA纳米新技术的研究现状与应用. 轻工学报, 2014, 29(1): 7-14.doi: 10.3969/j.issn.2095-476X.2014.01.002
10. [10]
  张勋才,孙军伟,王茜,崔光照. 基于DNA分子的信息安全技术研究综述. 轻工学报, 2016, 31(1): 67-74.doi: 10.3969/j.issn.2096-1553.2016.1.012
11. [11]
  王楠,王伟. 农田土壤中病原真菌DNA提取方法的研究. 轻工学报, 2013, 28(2): 54-58,63.doi: 10.3969/j.issn.2095-476X.2013.02.013
12. [12]
  王明花,杨光,张园厂,康萌萌,何领好,冯孝中,彭东来,张治红. DNA在石墨烯/金纳米/聚吡咯复合材料上的固定及杂交. 轻工学报, 2014, 29(4): 6-11.doi: 10.3969/j.issn.2095-476X.2014.04.002
13. [13]
  牛莹,张勋才,韩栋,王燕,崔光照,王子成. 一种基于DNA序列运算的信息隐藏方案. 轻工学报, 2016, 31(1): 61-66,88.doi: 10.3969/j.issn.2096-1553.2016.1.011
14. [14]
  王光耀,王仰勋,何声宝,白国强,张威,王英元,张晓慧,刘楠. DNA质量浓度测定在烟丝加工均质化中的应用研究. 轻工学报, 2022, 37(3): 88-93.doi: 10.12187/2022.03.012
15. [15]
  冯婷,张倩,董亚非. 基于二维DNA分子tiler自组装求解最大团问题. 轻工学报, 2011, 26(4): 94-97.doi: 10.3969/j.issn.1004-1478.2011.04.022
16. [16]
  鲁宜文,王东方,郭丽娜. 基于近似模型的动车组塞拉门携门架轻量化设计. 轻工学报, 2017, 32(5): 81-87.doi: 10.3969/j.issn.2096-1553.2017.5.011
17. [17]
  王金林,刘国庆,张金召,周子方,黄五星,邵惠芳,许自成,刘超. 三门峡烟区主栽烤烟两品种烟叶质量比较. 轻工学报, 2013, 28(6): 14-17.doi: 10.3969/j.issn.2095-476X.2013.06.004
18. [18]
  苏永士,许自成,秦璐,杜娟,陈彦春,苏富强. 三门峡烟区烤烟不同生育期气温和日照时数的特征分析. 轻工学报, 2011, 26(1): 22-25.doi: 10.3969/j.issn.1004-1478.2011.01.006
19. [19]
  刘足江,刘云. 环形无线网络呼叫接入控制模型研究. 轻工学报, 2012, 27(6): 97-100.doi: 10.3969/j.issn.2095-476X.2012.06.026
20. [20]
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沈阳化工大学材料科学与工程学院沈阳 110142

基于DNA链置换反应的圆环形逻辑门设计

Design of circular logic gate based on DNA strand displacement reaction

计量

通讯作者:陈斌, bchen63@163.com

基于DNA链置换反应的圆环形逻辑门设计

English Abstract

Design of circular logic gate based on DNA strand displacement reaction

目录

基于DNA链置换反应的圆环形逻辑门设计

Design of circular logic gate based on DNA strand displacement reaction

计量

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通讯作者:陈斌, bchen63@163.com

基于DNA链置换反应的圆环形逻辑门设计

English Abstract

Design of circular logic gate based on DNA strand displacement reaction

目录